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To this end, we mainly focused on the manipulation of two enzymes

Wei, W., Huang, L., Chen, L., He, H., Liu, Y., Feng, Y., Lin, F., Chen, H., He, Q., Zhao, J., & Li, H

The existence of this correlation is supported by preclinical studies in mouse xenograft models, which showed that the therapeutic inhibition of angiogenesis reduces tumor vascularization and causes hypoxia, and therefore may promote c-Met-mediated invasion of malignant cells [50]

This review highlights the potential of metabolomics, proteomics, miRNA, and MRI studies to advance our understanding of chronic diseases, and identifies key areas, such as the impact of altered lipid and energy metabolism, that warrant further investigation